WebMar 26, 2014 · For the G4/DNA system, the amount of free DNA decreases (about) linearly with the amount of added G4, till nearly all DNA is compacted at r charge ≈1. Assuming … WebPolymer-assisted Compaction ... Phorsphoramidites and supplies for DNA synthesis were purchased from Glen Research ... In a round bottom flask, a brush polymer (67 nmol) was dissolved in 2 mL DMF, to which fluorescein 5-thiosemicarbazide (1.43 …
Cooperative action in DNA condensation - ScienceDirect
WebThe modified polymer beget chemical-free in-situ synthesis of monodispersed ... The rheological properties were studied with the Anton Paar Modular Compact Rheometer equipment (MCR 102 parallel ... non-histone nuclear protein that is tightly linked to the cell cycle and does not appear to be expressed during DNA repair processes and ... WebOct 21, 2015 · PEGylation of synthetic polymers such as dendrimers is shown to reduce toxicity and increase biocompatibility and DNA transfection. 15-21 It is well demonstrated … flow chevrolet ws nc
Full article: Polymer-Assisted In Situ Synthesis of Silver ...
WebJun 17, 2024 · We have developed a non-cationic transfection vector in the form of a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side … WebAug 1, 1997 · The cationic polymers bind to DNA in a stoichiometry that is nearly 1:1 in primary amines to DNA phosphates. The apparent binding of all cationic polymers to DNA … WebDec 1, 2016 · 1. Brief historical perspective. Despite more than four decades of study, DNA compaction still remains an intriguing and elusive subject. The first studies began in the early 1970s, employing essentially multications and polycations as condensing agents [1], [2].At the same time, Lerman [3] reported the collapse of DNA through the combined … flow chevy