Hemi-protonated
Web23 dec. 2024 · I-Motif is a tetrameric cytosine-rich DNA structure with hemi-protonated cytosine: cytosine base pairs. Recent evidence showed that i-motif structures in human cells play regulatory roles in the genome. Therefore, characterization of novel i-motifs and investigation of their functional implication a …
Hemi-protonated
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WebUnder slightly acidic conditions, cytosine-rich DNA sequences can form non-canonical secondary structures called i-motifs, which occur as four stretches of cytosine repeats … Web23 mrt. 2024 · i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C⁺: C base pairs in C-rich DNA strands and play essential roles in the regulation of gene...
Web1 sep. 2024 · In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (C:C +). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. WebThe release of two protons, which stabilize the hemi-protonated cytosine pairs in the native i-motif, can be identified as the initial step for the occurrence of the unfolding process. By a systematic analysis of the proton motion, we are able to validate a …
Web22 dec. 1994 · At slightly acid or even neutral pH, oligodeoxynucleotides that include a stretch of cytidines form a tetramer structure in which two parallel-stranded duplexes have their hemi-protonated C.C+ base pairs face-to-face and fully intercalated, in a so-called i-motif, first observed serendipitously in [d(TC5)]4. WebThese results reveal that formation of only two hemi-protonated C:C + base pairs can lead to an apparent pK a comparable to those of cytosine rich sequences. Although the number of hemi-protonated base pairs is important for stability, capping interactions are also determinant for i-motif formation at slightly acidic or neutral pH.
Web21 jul. 2024 · i-Motifs are quadruplex DNA structures formed from sequences rich in cytosine and held together by intercalated, hemi-protonated cytosine-cytosine base pairs. These …
Webi-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C⁺: C base pairs in C-rich DNA strands and play essential roles in the … how to install canon 2560 printerWebhemiprotonated ( not comparable ) protonated at only half of the possible sites (typically, 1 of 2) quotations . This page was last edited on 29 September 2024, at … how to install canon g2010 printer without cdWeb22 feb. 2024 · hemi-protonated cytosine–cytosine+ (C:C+)base pairs (Fig-ure 1A).[8,9] i-DNAformation at physiological pH has been recently reported.[10,11] Moreover,the generation of an anti-body able to detect i-DNAhas proved its presence in the nucleus of human cells,arguing for regulatory roles in the genome,e.g.,at proto-oncogene promoters … how to install canon imagerunner 2525iWeb3 dec. 2015 · Similar C-rich sequences may, under acidic conditions, form i-motifs consisting of two parallel duplexes in a head to tail orientation held together by hemi-protonated C + -C pairs. We show that... how to install canon ir 2525 network printerWeb24 mrt. 2024 · i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C +: C base pairs in C-rich DNA strands and play essential roles in the regulation of gene expression.Here, we systematically investigated the impacts of K + on i-motif DNA folding using different buffer systems. We found that i-motif structures display … jon deane the mortgage storeWeb2 feb. 2024 · The detection and removal of heavy metal species in aquatic environments is of continued interest to address ongoing efforts in water security. This study was focused on the preparation and characterization of aniline grafted chitosan (CS-Ac-An), and evaluation of its adsorption properties with Cu(II) under variable conditions. Materials … how to install canon g1010 printer in laptopWebi-Motif (the name stems from “intercalated”), also known as i-DNA, is a pH-dependent four-stranded nucleic acid structure formed by cytosine-rich sequences via hemi-protonated and intercalated C C+base pairs. how to install canon ink cartridge pg-245