Glycosphingolipid psychosine
WebReceptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids ( By similarity ). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance ( PubMed: 27287411 ). May have a role in activation-induced cell death or differentiation … WebThe glycosphingolipid, psychosine (D-galactosyl- -1,1 sphingosine), accumulates to micromolar levels in GLD patients who lack the degradative enzyme galactosyl ceramidase. Here we document that an orphan G protein–coupled receptor, T cell death–associated gene 8, is a specific psychosine receptor.
Glycosphingolipid psychosine
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WebThe meaning of GLYCOSPHINGOLIPID is any of various lipids (as a cerebroside or a ganglioside) which are derivatives of ceramides, do not contain the phosphorus or the … WebG2A shares significant homology with three GPCRs including ovarian cancer GPCR (OGR1/GPR68), GPR4, and T cell death-associated gene 8 (TDAG8). Lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC) were reported as ligands for G2A and GPR4 and for OGR1 (SPC only), and a glycosphingolipid …
WebMar 20, 1995 · In the absence of GALC, the cytotoxic glycosphingolipid, psychosine (psy), accumulates in the nervous system. Psychosine accumulation preferentially affects oligodendrocytes, leading to progressive demyelination and infiltration of activated monocytes/macrophages into the CNS. GLD is characterized by motor defects, cognitive … WebApr 16, 2001 · The glycosphingolipid, psychosine ( d -galactosyl-β-1,1′ sphingosine), accumulates to micromolar levels in GLD patients who lack the degradative enzyme galactosyl ceramidase. Here we document that an orphan G protein–coupled receptor, T cell death–associated gene 8, is a specific psychosine receptor. ...
WebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details. WebPsychosine, a substrate of GALC and primary contributor to the pathology in GLD, was observed to be significantly elevated in the serum and CSF by 2 or 4 weeks of age, respectively, and steadily increased over the lifetime of affected animals. Importantly, psychosine concentration strongly correlated with disease severity.
WebDisorders that alter glycosphingolipid metabolism cause devastating neurodegenerative and demyelinating diseases. We show that deletion of the glycosphingolipid …
Web1. Structure and Occurrence. β-D-Galactosylceramide (Galβ1-1'Cer) is the principal glycosphingolipid in brain tissue, hence the trivial name "cerebroside", which was first conferred on it in 1874, although it was much later before it was properly characterized.In fact, galactosylceramides are found in all nervous tissues and indeed at low levels in all … merkury smart wifi doorbell camera reviewsWebThe emergency department is located at 80 Jesse Hill Jr. Drive, SE. Georgia Crisis and Access Line (GCAL) If you are experiencing a behavioral crisis, call the Georgia Crisis … how phase changing cooling works for batteryWebThe "psychosine hypothesis" has been refined by showing that psychosine disrupts lipid rafts and vesicular transport critical for the function of glia and neurons. The role … how pharmacy makes pillsWebPsychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture merkury smart wifi led bulb walmartWebReceptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids 1. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance 2. May have a role in activation-induced cell death or differentiation of T-cells (By similarity). merkury smart wifi doorbell camera appWebMay 1, 2001 · The glycosphingolipid, psychosine (d-galactosyl-beta-1,1' sphingosine), accumulates to micromolar levels in GLD patients who lack the degradative enzyme galactosyl ceramidase. how phenylamine is madeWebFeb 26, 2024 · α-Synuclein aggregation has been linked to Gaucher’s disease (GD) and Krabbe’s disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly … merkury smart wifi indoor camera